Sucrosomial Iron

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Sucrosomial ® Iron: A New Generation Iron for Improving ...

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Sucrosomial ® iron (SI) is an innovative oral iron formulation in which ferric pyrophosphate is protected by a phospholipid bilayer plus a sucrester matrix (sucrosome), which is absorbed through para-cellular and trans-cellular routes (M cells). This confers SI unique structural, physicochemical and pharmacokinetic characteristics, together ...

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Sucrosomial Iron Supplementation for the Treatment of Iron ...

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Iron deficiency anemia (IDA) is a common manifestation of Inflammatory Bowel Disease (IBD). Oral iron supplements are the treatment of choice, but are not always well tolerated. Sucrosomial ® iron (SI) may represent an alternative. This prospective study assessed the tolerability and effec …

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Safety and efficacy of sucrosomial iron in inflammatory ...

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Iron deficiency anemia (IDA) is one of the most common complications of inflammatory bowel disease (IBD). We planned a prospective study to address tolerability and efficacy of sucrosomial iron, a new oral formulation of ferric pyrophosphate, in IBD patients. Thirty patients with a confirmed diagnos …

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Sucrosomial Iron Supplementation in Anemic Patients With ...

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Patients treated with sucrosomial iron reported a lower severity of abdominal symptoms, such as abdominal and epigastric pain, abdominal bloating, and constipation, and a higher increase in general well-being (+33% vs. +21%) compared to the iron sulfate group. Sucrosomial iron can be effective in providing iron supplementation in difficult-to ...

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Oral Sucrosomial Iron Is as Effective as Intravenous ...

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Feb 12, 2021  · Sucrosomial ® Iron (SI) is an innovative oral iron formulation, in which ferric pyrophosphate is encapsulated in a phospholipid bilayer plus a sucrester matrix, which protect the digestive mucosa from direct contacts with iron and facilitate its absorption through para-cellular and trans-cellular routes . These features confer high ...

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Oral high-dose sucrosomial iron vs intravenous iron in ...

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Dec 02, 2020  · Sucrosomial® iron is a new oral iron formulation, in which ferric pyrophosphate is protected by a phospholipid bilayer membrane composed mainly by sunflower lecithin, enveloped in a sucrester matrix stabilized by other ingredients as tricalcium phosphate and starch, forming the “sucrosome,” absorbed as a vesicle-like structure, through ...

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Sucrosomial iron - Wikipedia

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Sucrosomial iron is a new oral iron preparation containing ferric pyrophosphate covered by phospholipids plus sucrose ester of fatty acid matrix. This allows the molecule to be absorbed in the gastrointestinal tract by trans-cellular, para-cellular and M-cells independently of hepcidin and due to gastro-resistant properties it does not causes the side effects such as gastric irritation …

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(PDF) Sucrosomial® Iron: A New Generation Iron for ...

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Sucrosomial® iron (SI) is an innovative oral iron formulation in which ferric pyrophosphate is protected by a phospholipid bilayer plus a sucrester matrix (sucrosome), which is …

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Sucrosomial® Iron: The story of success achieved by ...

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Mar 06, 2017  · Sucrosomial® Iron: international acknowledgement for Pisa iron. Andrea Lacorte, CEO of the Pharmanutra Group and exceptional sportsman. A rich portfolio that includes an international expedition to the North Pole in 2013, nutrition, animal feed and the NutraIngredients Product of the Year Award 2016 (NIA).

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Categories of Oral Iron | Iron Corner | SABM

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Dec 24, 2020  · Sucrosomial iron is an oral iron preparation consisting of ferric pyrophosphate protected by a phospholipid bilayer membrane made up of primarily a sunflower lecithin. 1 Preclinical data have shown that sucrosomial iron retains the iron in the sucrosome when in stomach acid, which allows intact sucrosomes to reach the small intestine where they ...

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Sucrosomial® Technology - SiderAL®

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Sucrosomial® Technology, designed and patented by PharmaNutra, helps to preserve, transport, protect and facilitate the absorption of certain essential nutrients for the human body, such as iron, selenium, zinc, iodine, calcium and magnesium.. What is Sucrosomial® Technology? The name Sucrosomial® Technology is derived from Sucrosome®, the complex of components …

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Sucrosomial Iron®: A New Highly Bioavaible Oral Iron ...

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Dec 03, 2015  · Results: The data showed that Sucrosomial Iron ¨ (Sideral ¨), is significantly more bioavaible than microencapsulated Ferric pyrophosphate ingredients, Lipofer ¨ and Sunactive ¨ and Ferrous Sulfate in Caco-2 cell model (Figure 1).

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Preliminary experience on the use of sucrosomial iron in ...

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Our study demonstrates that a therapy with sucrosomial iron in hemodialysis patients is safe and can maintain stable hemoglobin levels in a three-month period with a possible beneficial effect on oxidative stress parameters. However, the reduction of ferritin and transferrin saturation suggests that …

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Effects of Sucrosomial® iron in Pre-Clinical and Clinical ...

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Dec 07, 2017  · The role of Sucrosomial ® Iron on the inflammatory response, was studied in LPS induced HepG2 hepatoma cells. Cells were treated with Sucrosomial ® Iron and the levels of hepcidin were assessed 6, 18 and 24 hours after treatment.

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Innovative Oral Iron Supplement (Sucrosomial Iron®) Is ...

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Dec 03, 2015  · Sucrosomial Iron ¨ (Sideral ¨) is a new and still unique preparation of ferric pyrophosphate, useful for treatment of iron deficiency related anemia. Aim: we have previously performed a clinical study in which we showed that Sucrosomial iron is able to increase Hemoglobin level in CKD patients (Pisani et al., 2014).

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Pharmaceuticals | Free Full-Text | Sucrosomial® Iron: A ...

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Nov 04, 1997  · Sucrosomial iron has been also demonstrated to have a similar effectiveness, with lower risks, in clinical settings where IV iron was the usual treatment option (e.g., CKD, cancer, bariatric surgery, etc.) . Thus, the administration of oral SI emerges as a valuable first option for treating uncomplicated iron deficiency, especially for subjects ...

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Sucrosomial Iron Absorption Involve M Cells Interaction ...

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Dec 07, 2017  · Sucrosomial ® Iron, passed through M cells, was taken up by CD68+ macrophage cells as confirmed by ex-vivo experiments, in which fluorescein tagged Sucrosomial ® Iron was added to an isolated rat intestine using Hussing chamber-like model, then analyzed by immunohistochemistry. To study the reticuloendothelial system involvement, tissue ...

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The role of intravenous iron in anemia management and ...

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A new oral iron formulation, Sucrosomial iron, bypassing the normal way of absorption, seems to be cost-effective in correcting iron deficiency anemia at …

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Comparative Evaluation of Sucrosomial Iron and Iron Oxide ...

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Sucrosomial iron (SI) represents an innovative oral iron-containing carrier, in which ferric pyrophosphate is protected by a phospholipid bilayer membrane mainly from sunflower lecithin and sucrester matrix . Sucrester is a surfactant derived from the esterification of fatty acids with sucrose, which has recently been shown to behave as an ...

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Sucrosomial Iron®: A New Highly Bioavaible Oral Iron ...

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Dec 03, 2015  · Sucrosomial Iron treated cells display significant increase of Ferritin synthesis compared to Lipofer and SunActive treated cells. Disclosures Tarantino: Pharmanutra s.p.a.: Employment. Brilli: Pharmanutra s.p.a.: Employment. Author notes *Asterisk with author names denotes non-ASH members. © 2015 by the American Society of Hematology MD,*,3 ...

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Sideral Forte Pharmanutra 30 Capsules - Pharmacoline

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Jun 15, 2021  · Sideral Forte. In fact, Sideral Forte is a nutritional supplement based on Sucrosomial Iron ® (Sideral ® rm) and Vitamin C, useful to address any nutritional deficiencies or temporarily increase the organic needs of these nutrients. In addition, it is useful in cases where iron integration is necessary even for long periods.

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Sucrosomial Iron in Patients With Celiac Disease and IDA ...

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Sep 27, 2016  · Sucrosomial iron (Sideral® Forte) is a preparation of ferric pyrophosphate conveyed within a phospholipid membrane associated with ascorbic acid, is a new-generation oral iron which shows a high gastrointestinal absorption and high bioavailability with a low incidence of side effects due to lack of any direct contact with intestinal mucosa.

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Nutrients | Free Full-Text | Sucrosomial Iron ...

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Iron deficiency anemia (IDA) is a common manifestation of Inflammatory Bowel Disease (IBD). Oral iron supplements are the treatment of choice, but are not always well tolerated. Sucrosomial® iron (SI) may represent an alternative. This prospective study assessed the tolerability and effectiveness of SI, and quality of life (QoL) of IDA-IBD patients who were …

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Sucrosomial Technology Is Able to Promote Ferric Iron ...

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Dec 02, 2016  · CONCLUSIONS: these results showed that Sucrosomial technology is able to protect ferric iron from the gastric pH conferring the ability to reach covered the intestine for absorption and to cross intestinal epithelium through a passive route; thus minimizing the conventional oral iron side effects and increasing Hb and Ferritin levels in HL ...

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SideraAL sucrosomial iron - YouTube

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Sucrosomial iron. Sideral, the best oral iron. Proven

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PRIME PubMed | Sucrosomial Iron Supplementation for the ...

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Iron deficiency anemia (IDA) is a common manifestation of Inflammatory Bowel Disease (IBD). Oral iron supplements are the treatment of choice, but are not always well tolerated. Sucrosomial® iron (SI) may represent an alternative. This prospective study assessed the tolerability and effectiveness of SI, and quality of life (QoL) of IDA-IBD patients who were …

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Novel Oral Iron Therapies for Iron Deficiency Anemia in ...

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Jul 01, 2019  · Sucrosomial iron is an oral iron preparation consisting of ferric pyrophosphate protected by a phospholipid bilayer membrane. 75 The phospholipid layer is made primarily of a sunflower lecithin and sucrester matrix. 76 Sucrester is a surfactant created by esterification of fatty acids with sucrose (sucrose esters). Other ingredients such as ...

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Oral sucrosomial iron improves exercise capacity and ...

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Jan 09, 2021  · Oral sucrosomial iron improves exercise capacity and quality of life in heart failure with reduced ejection fraction and iron deficiency: a non-randomized, open-label, proof-of-concept study. Apostolos Karavidas, Department of Cardiology, G. Gennimatas General Hospital, Athens, Greece.

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FAQ?

What kind of iron is sucrosomial iron made of?

Sucrosomial iron is a new oral iron preparation containing ferric pyrophosphate covered by phospholipids plus sucrose ester of fatty acid matrix.

How does sucrosomial iron protect ferric pyrophosphate?

Sucrosomial ® Iron (SI) is an innovative oral iron formulation in which ferric pyrophosphate is protected by a phospholipid bilayer plus a sucrester matrix (sucrosome), which is absorbed through para-cellular and trans-cellular routes (M cells).

Why does sucrosomial iron not cause gastric irritation?

This allows the molecule to be absorbed in the gastrointestinal tract by trans-cellular, para-cellular and M-cells independently of hepcidin and due to gastro-resistant properties it does not causes the side effects such as gastric irritation which is commonly associated to oral iron.

Which is more bioavaible lipofer or sucrosomial iron?

Results: The data showed that Sucrosomial Iron ¨ (Sideral ¨ ), is significantly more bioavaible than microencapsulated Ferric pyrophosphate ingredients, Lipofer ¨ and Sunactive ¨ and Ferrous Sulfate in Caco-2 cell model (Figure 1). Au, A. P., Reddy, M. B. (2000).